Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
Type de proteíne
Recombinant
Origine
Cynomolgus
Source
HEK-293 Cells
Purification/Conjugué
Cette Fc epsilon RI/FCER1A protéine est marqué à la Fc Tag.
Fonction
Cynomolgus Fc epsilon RI alpha Protein, Fc Tag (BLI verified)
Séquence
Val 29 - Lys 204
Attributs du produit
Cynomolgus Fc epsilon RI alpha, Fc Tag (FCA-C5255) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Lys 204 (Accession # A0A7N9DA09-1).
SPR verified
FCER1A
Origine: Cynomolgus
Hôte: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Indications d'application
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.9 kDa. The protein migrates as 60-70 kDa under reducing (R) condition due to glycosylation.
Restrictions
For Research Use only
Format
Lyophilized
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
Stock
-20 °C
Stockage commentaire
-20°C
Antigène
Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
FCER1A Protein, FCE1A Protein, FcERI Protein, Iger01 Protein, RATIGER01 Protein, Fce1a Protein, Fcr-5 Protein, fcepsilonri Protein, Fc fragment of IgE receptor Ia Protein, Fc receptor, IgE, high affinity I, alpha polypeptide Protein, FCER1A Protein, Fcer1a Protein
Sujet
Synonyms: FCER1A,FCE1A,FcERI, Description: High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.