IL17C Protein (His-Avi Tag,Biotin)

N° du produit ABIN7199575

Détail du produit

Antigène: IL17C (Interleukin 17C (IL17C))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette IL17C protéine est marqué à la His-Avi Tag,Biotin.

Fonction: Biotinylated Mouse IL-17C Protein, His,Avitag™ (MALS verified)

Séquence: Asp 17 - Gln 194

Attributs du produit: Biotinylated Mouse IL-17C, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Asp 17 - Gln 194 (Accession # Q8K4C5-1).

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Classe de qualité: MALS verified

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 23.4 kDa. The protein migrates as 25-27 kDa under reducing (R) condition due to glycosylation.

Commentaires:

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, 0.5 M Arginine, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL17C (Interleukin 17C (IL17C))

Autre désignation: IL-17C (IL17C Produits)

Synonymes: IL17C Protein, il17-3 Protein, CX2 Protein, IL-17C Protein, IL-21 Protein, interleukin 17C Protein, interleukin 17c Protein, IL17C Protein, il17c Protein, Il17c Protein

Sujet: Synonyms: IL-17C,Cytokine CX2,IL17C,
Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

Poids moléculaire: 23.4 kDa

NCBI Accession: NP_665833

Pathways: Cellular Response to Molecule of Bacterial Origin