ACVR1 Protein (His tag)
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- Antigène Voir toutes ACVR1 (ACRV1) Protéines
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette ACVR1 protéine est marqué à la His tag.
- Fonction
- Recombinant Human ALK-2/ACVR1 Protein (Baculovirus, His Tag)
- Séquence
- Met 1-Val 124
- Attributs du produit
- A DNA sequence encoding the extracellular domain (Met 1-Val 124) of human ALK2 (Q04771) (Met 1-Val 124) was fused with a polyhistidine tag at the C-terminus.
- Pureté
- > 93 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ACRV1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- Autre désignation
- ALK-2/ACVR1 (ACRV1 Produits)
- Synonymes
- ACTRI Protein, ACVR1A Protein, ACVRLK2 Protein, ALK2 Protein, FOP Protein, SKR1 Protein, TSRI Protein, ActR-IA Protein, ActR-I Protein, ActRIA Protein, Acvr Protein, Acvrlk2 Protein, Alk-2 Protein, Alk8 Protein, D330013D15Rik Protein, Tsk7L Protein, actri Protein, acvr1 Protein, acvr1-a Protein, acvr1-b Protein, acvr1a Protein, acvrlk2 Protein, alk-2 Protein, alk2 Protein, alk8 Protein, fop Protein, sax Protein, skr1 Protein, tsri Protein, xALK-2 Protein, activin A receptor type 1 Protein, activin A receptor, type 1 Protein, activin A receptor type 1 S homeolog Protein, ACVR1 Protein, Acvr1 Protein, acvr1.S Protein
- Sujet
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Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
Synonym: Activin Receptor Type-1, Activin Receptor Type I, ACTR-I, Activin Receptor-Like Kinase 2, ALK-2, Serine/Threonine-Protein Kinase Receptor R1, SKR1, TGF-B Superfamily Receptor Type I, TSR-I, ACVR1, ACVRLK2,ACVR1A,ACVRLK2,ALK2,FOP,SKR1
- Poids moléculaire
- 12.8kDa
- UniProt
- Q04771
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