AGRP Protein (His tag)
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- Antigène Voir toutes AGRP Protéines
- AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
- Type de proteíne
- Recombinant
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette AGRP protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse AgRP/AGRP Protein (His Tag)
- Séquence
- Met 1-Thr 131
- Attributs du produit
- A DNA sequence encoding the extracellular domain of mouse AGRP (P56473) (Met 1-Thr 131) was expressed, with a C-terminal polyhistidine tag.
- Pureté
- > 80 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product AGRP Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- AGRP (Agouti Related Protein Homolog (Mouse) (AGRP))
- Autre désignation
- AgRP/AGRP (AGRP Produits)
- Synonymes
- AGRT Protein, ART Protein, ASIP2 Protein, Agrt Protein, Art Protein, agouti related neuropeptide Protein, agouti-related protein pseudogene Protein, AGRP Protein, Agrp Protein, LOC100352591 Protein
- Sujet
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Background: Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
Synonym: Agrt,Art
- Poids moléculaire
- 13.7 kDa
- UniProt
- P56473
- Pathways
- Feeding Behaviour, Photoperiodism
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