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BNIP3L/NIX Protéine

BNIP3L Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 88 % as determined by reducing SDS-PAGE.
N° du produit ABIN7317369
  • Antigène Voir toutes BNIP3L/NIX (BNIP3L) Protéines
    BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
    Type de proteíne
    Recombinant
    Origine
    • 4
    • 1
    Humain
    Source
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Human BNIP3L Protein
    Séquence
    Ser 2-Lys 187
    Attributs du produit
    A DNA sequence encoding the human BNIP3L (NP_004322.1) (Ser 2-Lys 187) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
    Pureté
    > 88 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product BNIP3L Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 1 mM DTT, pH 8.0
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
    Autre désignation
    BNIP3L (BNIP3L Produits)
    Synonymes
    BNIP3a Protein, NIX Protein, NIP3 Protein, Nix Protein, Nip3 Protein, C86132 Protein, D14Ertd719e Protein, Nip3L Protein, bnip3l Protein, nip3 Protein, zgc:110478 Protein, bnip3l2 Protein, wu:fb52b03 Protein, wu:fc02h04 Protein, BCL2 interacting protein 3 like Protein, BCL2 interacting protein 3 Protein, BCL2/adenovirus E1B interacting protein 3 Protein, BCL2/adenovirus E1B interacting protein 3-like Protein, BCL2/adenovirus E1B interacting protein 3-like b Protein, BCL2/adenovirus E1B interacting protein 3-like a Protein, BNIP3L Protein, BNIP3 Protein, Bnip3l Protein, Bnip3 Protein, bnip3lb Protein, bnip3la Protein
    Sujet

    Background: The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to rid the cells of the last remaining 'living' characteristic, thus completing the march from 'living' to 'dead' within the hair follicle. during retinal development tissue hypoxia triggers HIF1A/HIF-1 stabilization, resulting in increased expression of the mitophagy receptor BNIP3L/NIX. BNIP3L-dependent mitophagy results in a metabolic shift toward glycolysis essential for RGC neurogenesis. BNIP3L could be a potential therapeutic target for ischemic stroke

    Synonym: BNIP3a,NIX

    Poids moléculaire
    20.4 kDa
    Pathways
    Autophagy
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