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BID Protéine

BID Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7317857
  • Antigène Voir toutes BID Protéines
    BID (BH3 Interacting Domain Death Agonist (BID))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 10
    • 4
    • 3
    • 1
    • 1
    Humain
    Source
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Human BID Protein (Active)
    Séquence
    Met 1-Asp 195
    Attributs du produit
    A DNA sequence encoding the human BID isoform 1 (P55957-1) (Met 1-Asp 195) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
    Pureté
    > 90 % as determined by reducing SDS-PAGE.
    Biological Activity Comment
    1. Measured by its binding ability in a functional ELISA.2. Immobilized human BID at 10 μg/mL (100 μl/well) can bind  biotinylated human BCL2L1, The EC50 of biotinylated human BCL2L1 is 7.1 ng/mL.3. Immobilized human BID at 10 μg/mL (100 μl/well) can bind  biotinylated mouse BCL2L1, The EC50 of biotinylated mouse BCL2L1 is 5.6 ng/mL.
    Top Product
    Discover our top product BID Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 40 mM Tris, 150 mM NaCl, pH 8.0
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    BID (BH3 Interacting Domain Death Agonist (BID))
    Autre désignation
    BID (BID Produits)
    Synonymes
    FP497 Protein, 2700049M22Rik Protein, AI875481 Protein, AU022477 Protein, BID Protein, bid Protein, si:ch211-238n5.6 Protein, fp497 Protein, xbid Protein, DKFZp469E066 Protein, BH3 interacting domain death agonist Protein, BH3 interacting domain death agonist S homeolog Protein, BID Protein, Bid Protein, bida Protein, bid.S Protein, bid Protein
    Sujet

    Background: The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.

    Synonym: BH3-Interacting Domain Death Agonist, p22 BID, BID

    Pathways
    Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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