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BRD4 Protéine

BRD4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >95 % as determined by reducing SDS-PAGE.
N° du produit ABIN7319875
  • Antigène Voir toutes BRD4 Protéines
    BRD4 (Bromodomain Containing 4 (BRD4))
    Type de proteíne
    Recombinant
    Origine
    Humain
    Source
    • 3
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Human BRD4 (N-10His-Flag)
    Séquence
    Glu49-Glu460
    Attributs du produit
    Recombinant Human Bromodomain-containing protein 4 is produced by our E.coli expression system and the target gene encoding Glu49-Glu460 is expressed with a 10His, Flag tag at the N-terminus.
    Pureté
    >95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product BRD4 Protéine
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 1 mM DTT, 10 % Glycerol, pH 7.5.
    Stock
    -20 °C
    Stockage commentaire
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Antigène
    BRD4 (Bromodomain Containing 4 (BRD4))
    Autre désignation
    BRD4 (BRD4 Produits)
    Synonymes
    brd4-b Protein, BRD4 Protein, fb18g03 Protein, wu:fb18g03 Protein, CAP Protein, HUNK1 Protein, HUNKI Protein, MCAP Protein, Brd5 Protein, WI-11513 Protein, bromodomain containing 4 L homeolog Protein, bromodomain containing 4 Protein, bromodomain-containing protein 4 Protein, brd4.L Protein, BRD4 Protein, brd4 Protein, LOC100409351 Protein, Brd4 Protein
    Sujet

    Background: Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for acetylated lysine residues on histones, while the NET domain may function by promoting phosphorylation of the C-terminal domain (CTD) of RNA Polymerase II. Some specific inhibitors of BRD4 that prevent binding to acetylated histones by binding Asn-140 and Asn-433 are promising therapeutic molecules for the treatment of leukemias. BRD4 is a potential therapeutic target in many diseases including breast cancer, AML, multiple myeloma, colon cancer and others.

    Synonym: HUNK1, HUNK1bromodomain-containing protein 4, HUNKI, MCAP

    Poids moléculaire
    49 kDa
    UniProt
    O60885
    Pathways
    Chromatin Binding, SARS-CoV-2 Protein Interactome
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