BRD4 Protéine
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- Antigène Voir toutes BRD4 Protéines
- BRD4 (Bromodomain Containing 4 (BRD4))
- Type de proteíne
- Recombinant
- Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Fonction
- Recombinant Human BRD4 (N-10His-Flag)
- Séquence
- Glu49-Glu460
- Attributs du produit
- Recombinant Human Bromodomain-containing protein 4 is produced by our E.coli expression system and the target gene encoding Glu49-Glu460 is expressed with a 10His, Flag tag at the N-terminus.
- Pureté
- >95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product BRD4 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 1 mM DTT, 10 % Glycerol, pH 7.5.
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- BRD4 (Bromodomain Containing 4 (BRD4))
- Autre désignation
- BRD4 (BRD4 Produits)
- Synonymes
- brd4-b Protein, BRD4 Protein, fb18g03 Protein, wu:fb18g03 Protein, CAP Protein, HUNK1 Protein, HUNKI Protein, MCAP Protein, Brd5 Protein, WI-11513 Protein, bromodomain containing 4 L homeolog Protein, bromodomain containing 4 Protein, bromodomain-containing protein 4 Protein, brd4.L Protein, BRD4 Protein, brd4 Protein, LOC100409351 Protein, Brd4 Protein
- Sujet
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Background: Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for acetylated lysine residues on histones, while the NET domain may function by promoting phosphorylation of the C-terminal domain (CTD) of RNA Polymerase II. Some specific inhibitors of BRD4 that prevent binding to acetylated histones by binding Asn-140 and Asn-433 are promising therapeutic molecules for the treatment of leukemias. BRD4 is a potential therapeutic target in many diseases including breast cancer, AML, multiple myeloma, colon cancer and others.
Synonym: HUNK1, HUNK1bromodomain-containing protein 4, HUNKI, MCAP
- Poids moléculaire
- 49 kDa
- UniProt
- O60885
- Pathways
- Chromatin Binding, SARS-CoV-2 Protein Interactome
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