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Cadherin 12 Protein (His tag)

Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by reducing SDS-PAGE.
N° du produit ABIN7317919
  • Antigène Voir toutes Cadherin 12 Protéines
    Cadherin 12
    Type de proteíne
    Recombinant
    Origine
    Humain
    Source
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Cadherin 12 protéine est marqué à la His tag.
    Fonction
    Recombinant Human Cadherin-12/CDH12 Protein (His Tag)
    Séquence
    Met 1-Ala 605
    Attributs du produit
    A DNA sequence encoding the pro form of human CDH12 (NP_001783.2) extracellular domain (Met 1-Ala 605) was fused with a polyhistidine tag at the C-terminus.
    Pureté
    > 80 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product Cadherin 12 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 50 mM sodium citrate, 50 mM NaCl, 2 mM CaCl2, pH 6.0
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    Cadherin 12
    Autre désignation
    Cadherin-12/CDH12 (Cadherin 12 Produits)
    Synonymes
    CDHB Protein, Cdhb Protein, RGD1566350 Protein, cdh12 Protein, cadherin 12 Protein, cadherin-12 Protein, CDH12 Protein, Cdh12 Protein, LOC570372 Protein
    Sujet

    Background: Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

    Synonym: CDHB

    Poids moléculaire
    66 kDa
    NCBI Accession
    NP_001783
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