CAMK2A Protein (GST tag)
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- Antigène Voir toutes CAMK2A Protéines
- CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette CAMK2A protéine est marqué à la GST tag.
- Fonction
- Recombinant Human CAMK2A/CAMKA Protein (GST Tag)(Active)
- Séquence
- Met 1-His 478
- Attributs du produit
- A DNA sequence encoding the human CAMK2A isoform 2 (NP_741960.1) (Met 1-His 478) was fused with the GST tag at the N-terminus.
- Pureté
- > 85 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 160 nmol/min/mg using Autocamtide-2 synthetic peptide (KKALRRQETVDAL-amide) as substrate.
- Top Product
- Discover our top product CAMK2A Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM Reduced Glutathione, pH 8.0
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))
- Autre désignation
- CAMK2A/CAMKA (CAMK2A Produits)
- Synonymes
- camk2 Protein, camk2b Protein, zgc:112538 Protein, zgc:123320 Protein, CAMKA Protein, CaMKII Protein, R74975 Protein, mKIAA0968 Protein, PK2CDD Protein, PKCCD Protein, calcium/calmodulin dependent protein kinase II alpha Protein, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog Protein, calcium/calmodulin-dependent protein kinase II alpha Protein, CAMK2A Protein, camk2a.S Protein, camk2a Protein, Camk2a Protein
- Sujet
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Background: Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase II is thought to be an important mediator of learning and memory and is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.
Synonym: CAMKA
- Poids moléculaire
- 80.3 kDa
- NCBI Accession
- NP_741960
- Pathways
- Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction
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