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CPE Protein (Fc Tag)

CPE Origine: Humain Hôte: HEK-293 Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
N° du produit ABIN7194611
  • Antigène Voir toutes CPE Protéines
    CPE (Carboxypeptidase E (CPE))
    Type de proteíne
    Recombinant
    Origine
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 5
    • 4
    • 3
    • 2
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette CPE protéine est marqué à la Fc Tag.
    Fonction
    Recombinant Human Carboxypeptidase E/CPE Protein (Fc Tag)
    Séquence
    Met 1-Ser 453
    Attributs du produit
    A DNA sequence encoding the human carboxypeptidase E (CPE) precursor (NP_001864.1) (Met 1-Ser 453) was expressed with the C-terminal fused Fc region of human IgG1.
    Pureté
    > 85 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product CPE Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    CPE (Carboxypeptidase E (CPE))
    Autre désignation
    Carboxypeptidase E/CPE (CPE Produits)
    Synonymes
    CPE Protein, CPH Protein, Cph-1 Protein, Cph1 Protein, R74677 Protein, fat Protein, CARBE Protein, Cph Protein, si:ch211-198g9.2 Protein, zgc:85981 Protein, carboxypeptidase E Protein, carboxypeptidase E L homeolog Protein, CPE Protein, cpe Protein, Cpe Protein, cpe.L Protein
    Sujet

    Background: Carboxypeptidase E (CPE), also known as Carboxypeptidase H, is a peripheral membrane protein and a zinc metallocarboxypeptidase, and the conversion of proCPE into CPE occurs primarily in secretory vesicles. The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. The enzymatic activity is enhanced by millimolar concentrations of Co2+. It has also been proposed that membrane-associated carboxypeptidase E acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway.Its interaction with glycosphingolipid-cholesterol rafts at the TGN facilitates the targeting. Mutations in this gene are implicated in type I I diabetes due to impaired glucose clearance and insulin resistance.

    Synonym: Carboxypeptidase E(CPE for short); Carboxypeptidase H; Enkephalin convertase; Prohormone-processing carboxypeptidase

    Poids moléculaire
    74.6 kDa
    NCBI Accession
    NP_001864
    Pathways
    Peptide Hormone Metabolism, Synaptic Membrane
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