Cathepsin B Protein (CTSB) (His tag)

N° du produit ABIN7318252

Détail du produit

Antigène: Cathepsin B (CTSB)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Cathepsin B protéine est marqué à la His tag.

Fonction: Recombinant Human Cathepsin B/CTSB Protein (His Tag)

Séquence: Arg18-Ile339

Attributs du produit: Recombinant Human Cathepsin B is produced by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Cathepsin B (CTSB)

Autre désignation: Cathepsin B/CTSB (CTSB Produits)

Sujet:

Background: Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes

Synonym: Cathepsin B, APP Secretase, APPS, Cathepsin B1, CTSB, CPSB

Poids moléculaire: 36.9 kDa

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades