CD16 Protein (CD16) (His tag)

N° du produit ABIN7194703

Détail du produit

Antigène: CD16

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD16 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD16 Protein (His Tag)(Active)

Séquence: Met 1-Thr 215

Attributs du produit: A DNA sequence encoding the mouse FCGR3 (P08508-1) extracellular domain (Met 1-Thr 215) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized mouse FCGR3-His at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1The EC50 of biotinylated human IgG1 is 0.12-0.28 μg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD16

Autre désignation: CD16 (CD16 Produits)

Synonymes: Fcgr3 Protein, Fcgr3a Protein, CD16 Protein, FCGR3 Protein, FCGR3@ Protein, CD16b Protein, FCG3 Protein, FCR-10 Protein, FCRIII Protein, FCRIIIb Protein, FcRIII Protein, Fc fragment of IgG, low affinity IIa, receptor Protein, Fc fragment of IgG, low affinity IIIa, receptor (CD16a) Protein, Fc fragment of IgG receptor IIIb Protein, Fc fragment of IgG receptor IIIa Protein, Fc receptor, IgG, low affinity III Protein, Fc-gamma RIII Protein, Fcgr2a Protein, FCGR3A Protein, FCGR3B Protein, Fcgr3 Protein, FCGR3 Protein

Sujet:

Background: Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

Synonym: CD16 Protein, Mouse

Poids moléculaire: 22.6 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process