CD226 Protein (CD226) (His tag)

N° du produit ABIN7320356

Détail du produit

Antigène: CD226

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette CD226 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD226/DNAM-1 Protein (His Tag)(Active)

Séquence: Met 1-Pro 254

Attributs du produit: A DNA sequence encoding the mouse DNAM1 (NP_848802.2) extracellular domain (Met 1-Pro 254) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized mouse DNAM1 at 2 μg/ml (100 μl/well) can bind mouse CD155 with a linear ranger of 6.4-160 ng/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD226

Autre désignation: CD226/DNAM-1 (CD226 Produits)

Synonymes: CD226 Protein, cd226 Protein, zgc:158817 Protein, BC051526 Protein, DNAM-1 Protein, DNAM1 Protein, Pta1 Protein, TLiSA1 Protein, PTA1 Protein, CD226 molecule Protein, CD226 antigen Protein, CD226 Protein, cd226 Protein, Cd226 Protein

Sujet:

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.Immune CheckpointImmune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: CD226 antigen; platelet and T cell activation antigen 1; CD226 molecule; DNAM1 adhesion glycoprotein; DNAM-1;DNAX accessory molecule-1; DNAX accessory molecule 1; PTA1; T lineage-specific activation antigen 1 antigen; CD226; PTA1; TLiSA1;BC051526;DNAM-1;DNAM1;Pta1;TLiSA1

Poids moléculaire: 28.2 kDa

NCBI Accession: NP_848802

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints