CD59 Protein (CD59) (His tag)

N° du produit ABIN7319910

Détail du produit

Antigène: CD59

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette CD59 protéine est marqué à la His tag.

Fonction: Recombinant Human CD59 (C-6His)

Séquence: Leu26-Asn102

Attributs du produit: Recombinant Human CD59 Glycoprotein is produced by our Mammalian expression system and the target gene encoding Leu26-Asn102 is expressed with a 6His tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD59

Autre désignation: CD59 (CD59 Produits)

Synonymes: 16.3A5 Protein, 1F5 Protein, EJ16 Protein, EJ30 Protein, EL32 Protein, G344 Protein, HRF-20 Protein, HRF20 Protein, MAC-IP Protein, MACIF Protein, MEM43 Protein, MIC11 Protein, MIN1 Protein, MIN2 Protein, MIN3 Protein, MIRL Protein, MSK21 Protein, p18-20 Protein, Cd59a Protein, Cd59b Protein, MACIP Protein, CD59 molecule (CD59 blood group) Protein, CD59 molecule Protein, CD59 Protein, Cd59 Protein

Sujet:

Background: CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

Synonym: 1F5 antigen, 1F5, 20 kDa homologous restriction factor, CD59 antigen, CD59 glycoprotein, CD59, HRF20, HRF-20, MACIF, MAC-IP, MIC11, MIC11MSK21, MIN1, MIN2, MIN3, MIRL, p18-20, 16.3A5, EL32, FLJ38134, FLJ92039, G344

Poids moléculaire: 9.8 kDa

UniProt: P13987

Pathways: Système du Complément