CD68 Protein (AA 1-319) (His tag)

N° du produit ABIN7317626

Détail du produit

Antigène: CD68 (CD68 Molecule (CD68))

Type de proteíne: Recombinant

Attributs du protein: AA 1-319

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette CD68 protéine est marqué à la His tag.

Fonction: Recombinant Human CD68/Macrosialin Protein (aa 1-319, His Tag)

Séquence: Met 1-Ser 319

Attributs du produit: A DNA sequence encoding the human CD68 (Met 1-Ser 319) was expressed, with a C-terminal polyhistidine tag.

Pureté: > 98 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD68 (CD68 Molecule (CD68))

Autre désignation: CD68/Macrosialin (CD68 Produits)

Synonymes: Lamp4 Protein, Scard1 Protein, gp110 Protein, GP110 Protein, LAMP4 Protein, SCARD1 Protein, CD68 molecule Protein, CD68 antigen Protein, Cd68 molecule Protein, CD68 Protein, Cd68 Protein

Sujet:

Background: Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Synonym: GP110;LAMP4;SCARD1

Poids moléculaire: 32.9 kDa