CD93 Protein (CD93) (AA 1-580) (His tag)

N° du produit ABIN7317351

Détail du produit

Antigène: CD93

Type de proteíne: Recombinant

Attributs du protein: AA 1-580

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD93 protéine est marqué à la His tag.

Fonction: Recombinant Human CD93/C1QR1 Protein (aa 1-580, His Tag)

Séquence: Met 1-Lys 580

Attributs du produit: A DNA sequence encoding the human CD93 (Q9NPY3) extracellular domain (Met 1-Lys 580) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD93

Autre désignation: CD93/C1QR1 (CD93 Produits)

Synonymes: 6030404G09Rik Protein, AA145088 Protein, AA4.1 Protein, AW555904 Protein, C1qr1 Protein, C1qrp Protein, Ly68 Protein, C1QR1 Protein, C1qR(P) Protein, C1qRP Protein, CDw93 Protein, ECSM3 Protein, MXRA4 Protein, dJ737E23.1 Protein, C1qRp Protein, CD93 antigen Protein, CD93 molecule Protein, Cd93 Protein, CD93 Protein

Sujet:

Background: CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

Synonym: Complement Component C1q Receptor, C1q/MBL/SPA Receptor, C1qR, C1qR(p), C1qRp, CDw93, Complement Component 1 q Subcomponent Receptor 1, Matrix-Remodeling-Associated Protein 4CD93, C1QR1, MXRA4

Poids moléculaire: 59.6 kDa

UniProt: Q9NPY3