Cell Adhesion Molecule 4 Protein (CADM4) (Fc Tag)

N° du produit ABIN7195018

Détail du produit

Antigène: Cell Adhesion Molecule 4 (CADM4)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Cell Adhesion Molecule 4 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human CADM4/IGSF4C/NECL-4 Protein (Fc Tag)

Séquence: Met 1-Tyr323

Attributs du produit: A DNA sequence encoding the human CADM4 (NP_660339.1) (Met1-Tyr323) was expressed with the Fc region of human IgG1 at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Cell Adhesion Molecule 4 (CADM4)

Autre désignation: CADM4/IGSF4C/NECL-4 (CADM4 Produits)

Synonymes: CADM4 Protein, IGSF4C Protein, zgc:101704 Protein, NECL4 Protein, Necl-4 Protein, TSLL2 Protein, synCAM4 Protein, Igdf4c Protein, Igsf4c Protein, Tsll2 Protein, Upar Protein, cell adhesion molecule 4 Protein, cell adhesion molecule 4 L homeolog Protein, CADM4 Protein, cadm4 Protein, Cadm4 Protein, cadm4.L Protein

Sujet:

Background: Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.

Synonym: IGSF4C,Necl-4,NECL4,synCAM4,TSLL2

Poids moléculaire: 60.1 kDa

NCBI Accession: NP_660339