CLDN18.2 protein (His tag)

N° du produit ABIN7319933

Détail du produit

Antigène: CLDN18.2

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: His tag

Fonction: Recombinant Human CLDN18.2(N-6His,C-Avi)

Attributs du produit: Biotinylated Recombinant Human CLDN18.2 is produced by our E.coli expression system and the targetgene encoding extracellular is expressed with a 6His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per g as determined by the LAL method.

Biological Activity Comment: Test in progress

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 8M Urea,150 mM NaCl, 5 mM β-ME, pH 8.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CLDN18.2

Sujet:

Background: Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2.IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Synonym: Claudin-18.2, CLDN18

Poids moléculaire: 12.6 kDa