Coxsackie Adenovirus Receptor Protein (His tag,Fc Tag)
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- Antigène Voir toutes Coxsackie Adenovirus Receptor (CXADR) Protéines
- Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Coxsackie Adenovirus Receptor protéine est marqué à la His tag,Fc Tag.
- Fonction
- Recombinant Mouse CXADR/CAR Protein (His & Fc Tag)(Active)
- Séquence
- Met 1-Gly 237
- Attributs du produit
- A DNA sequence encoding the mouse CXADR (NP_001020363.1) extracellular domain (Met 1-Gly 237) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- Pureté
- > 92 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of mouse neutrophils. When 5 x 10E4 cells/well are added to CXADR-coated plates (4 μg/ml and 100 μl/well), approximately 20%-40% will adhere specifically after 60 minutes at 37°C.
- Top Product
- Discover our top product CXADR Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))
- Autre désignation
- CXADR/CAR (CXADR Produits)
- Synonymes
- CAR Protein, CAR4/6 Protein, HCAR Protein, Car1 Protein, car Protein, cb331 Protein, fb76g12 Protein, wu:fb76g12 Protein, 2610206D03Rik Protein, AU016810 Protein, AW553441 Protein, MCAR Protein, MCVADR Protein, hcar Protein, xCAR Protein, CXADR Protein, CXADR, Ig-like cell adhesion molecule Protein, coxsackie virus and adenovirus receptor Protein, CXADR, Ig-like cell adhesion molecule L homeolog Protein, CXADR Protein, Cxadr Protein, cxadr Protein, cxadr.L Protein
- Sujet
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Background: CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.
Synonym: Coxsackievirus and adenovirus receptor homolog;CAR;Cxadr;CVB3 BP;MCVADR
- Poids moléculaire
- 52 kDa
- NCBI Accession
- NP_001020363
- Pathways
- Cell-Cell Junction Organization
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