EPH Receptor B2 Protein (EPHB2) (His tag,Fc Tag)

N° du produit ABIN7317769

Détail du produit

Antigène: EPH Receptor B2 (EPHB2)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette EPH Receptor B2 protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Human EphB2 Protein (His & Fc Tag)(Active)

Séquence: Met 1-Leu 543

Attributs du produit: A DNA sequence encoding the extracellular domain (Met 1-Leu 543) of human EphB2 (NP_059145.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind recombinant human EphrinB2 in a functional ELISA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: EPH Receptor B2 (EPHB2)

Autre désignation: EphB2 (EPHB2 Produits)

Synonymes: CAPB Protein, DRT Protein, EK5 Protein, EPHT3 Protein, ERK Protein, Hek5 Protein, PCBC Protein, Tyro5 Protein, ERK2 Protein, ERT1 Protein, MAPK2 Protein, P42MAPK Protein, PRKM1 Protein, PRKM2 Protein, p38 Protein, p40 Protein, p41 Protein, p41mapk Protein, RGD1564232 Protein, Cek5 Protein, Drt Protein, ETECK Protein, Erk Protein, Nuk Protein, Prkm5 Protein, Qek5 Protein, Sek3 Protein, cek5 Protein, ephb2 Protein, xEphB2 Protein, si:ch73-160e9.1 Protein, tpx2 Protein, wu:fb09e10 Protein, wu:fc64a03 Protein, wu:fi18g12 Protein, zgc:112296 Protein, EPH receptor B2 Protein, mitogen-activated protein kinase 1 Protein, Eph receptor B2 Protein, EPH receptor B2 L homeolog Protein, eph receptor B2a Protein, eph receptor B2b Protein, EPHB2 Protein, MAPK1 Protein, Ephb2 Protein, ephb2.L Protein, ephb2a Protein, ephb2b Protein

Sujet:

Background: Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Synonym: CAPB,DRT,EK5,EPHT3,ERK,Hek5,PCBC,Tyro5

Poids moléculaire: 86 kDa

NCBI Accession: NP_059145

Pathways: Signalisation RTK, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins