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EPH Receptor B6 Protein (EPHB6)

EPHB6 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7195561
  • Antigène Voir toutes EPH Receptor B6 (EPHB6) Protéines
    EPH Receptor B6 (EPHB6)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 4
    • 1
    Humain
    Source
    • 3
    • 1
    • 1
    HEK-293 Cells
    Fonction
    Recombinant Human EphB6 Protein (Active)
    Séquence
    Met 1-Ser 579
    Attributs du produit
    The mature form of human EphB6 (NP_004436.1) extracellular domain (Met 1-Ser 579) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA.Immobilized human EphB6 at 10 μg/mL (100 μl/well) can bind biotinylated human EFNB2-Fch with a linear range of 1.56-50 ng/mL.
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    Discover our top product EPHB6 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    EPH Receptor B6 (EPHB6)
    Autre désignation
    EphB6 (EPHB6 Produits)
    Synonymes
    CEK9 Protein, EPHB5 Protein, Cekl Protein, Mep Protein, HEP Protein, EPH receptor B6 Protein, Eph receptor B6 Protein, EPHB6 Protein, Ephb6 Protein
    Sujet

    Background: Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.

    Synonym: HEP

    Poids moléculaire
    60.4 kDa
    NCBI Accession
    NP_004436
    Pathways
    Signalisation RTK, Hormone Transport
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