Ezrin Protein (EZR)

N° du produit ABIN7319618

Détail du produit

Antigène: Ezrin (EZR)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Recombinant Human Ezrin/EZR Protein

Séquence: Met1-Leu586

Attributs du produit: Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 10 mM Hepes, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Ezrin (EZR)

Autre désignation: Ezrin/EZR (EZR Produits)

Synonymes: CVIL Protein, CVL Protein, VIL2 Protein, ezr Protein, vil2 Protein, wu:fc05c03 Protein, wu:fj31d06 Protein, cvil Protein, cvl Protein, Vil2 Protein, AW146364 Protein, R75297 Protein, p81 Protein, ezr.S Protein, ezrin Protein, ezrin b Protein, ezrin L homeolog Protein, EZR Protein, ezrb Protein, ezr Protein, Ezr Protein, ezr.L Protein

Sujet:

Background: Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.

Synonym: Ezrin, Cytovillin, Villin-2, p81, EZR, VIL2

Poids moléculaire: 69.4 kDa

UniProt: P15311

Pathways: Maintenance of Protein Location