GAD65 Protéine

N° du produit ABIN7320200

Détail du produit

Antigène: GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Fonction: Recombinant Mouse GAD65/GAD2/GAD-2 Protein

Séquence: Met 1-Leu 585

Attributs du produit: A DNA sequence encoding the mouse GAD2 (NP_032104.2) (Met 1-Leu 585) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 10 % glycerol, 3 mM DTT, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))

Autre désignation: GAD65/GAD2/GAD-2 (GAD2 Produits)

Synonymes: GAD65 Protein, gad65 Protein, F12P19.12 Protein, F12P19_12 Protein, GLUTAMATE DECARBOXYLASE 2 Protein, glutamate decarboxylase 2 Protein, zgc:112198 Protein, 6330404F12Rik Protein, GAD(65) Protein, Gad-2 Protein, glutamate decarboxylase 2 Protein, glutamate decarboxylase 1 Protein, glutamic acid decarboxylase 2 Protein, GAD2 Protein, PTRG_06148 Protein, LOC9324534 Protein, Gad2 Protein, GAD1 Protein, gad2 Protein

Sujet:

Background: Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of the group II decarboxylase family. GAD2 is identified as a major autoantigen in insulin-dependent diabetes. GAD2 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. GAD2 may also play a role in the stiff man syndrome. GAD2 is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. GABA is synthesized in brain by two isoforms of glutamic acid decarboxylase (Gad), GAD1 and GAD2. GAD1 provides most of the GABA in brain, but GAD2 can be rapidly activated in times of high GABA demand. Mice lacking GAD2 are viable whereas deletion of GAD1 is lethal. Deletion of GAD2 increased ethanol palatability and intake and slightly reduced the severity of ethanol-induced withdrawal.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: 6330404F12Rik;GAD(65);Gad-2;GAD65

Poids moléculaire: 65.4 kDa

NCBI Accession: NP_032104