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GZMB Protein (His tag)

GZMB Origine: Humain Hôte: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE.
N° du produit ABIN7195987
  • Antigène Voir toutes GZMB Protéines
    GZMB (Granzyme B (GZMB))
    Type de proteíne
    Recombinant
    Origine
    • 8
    • 7
    • 3
    • 1
    • 1
    Humain
    Source
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette GZMB protéine est marqué à la His tag.
    Fonction
    Recombinant Human Granzyme B/GZMB Protein (His Tag)
    Séquence
    Met 1-Tyr 247
    Attributs du produit
    A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.
    Pureté
    > 97 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product GZMB Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    GZMB (Granzyme B (GZMB))
    Autre désignation
    Granzyme B/GZMB (GZMB Produits)
    Synonymes
    CCPI Protein, CGL-1 Protein, CGL1 Protein, CSP-B Protein, CSPB Protein, CTLA1 Protein, CTSGL1 Protein, HLP Protein, SECT Protein, granzyme B Protein, GZMB Protein
    Sujet

    Background: Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.

    Synonym: CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT

    Poids moléculaire
    27 kDa
    NCBI Accession
    NP_004122
    Pathways
    Apoptose, Caspase Cascade in Apoptosis
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