GAMT Protein (His tag)

N° du produit ABIN7318555

Détail du produit

Antigène: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GAMT protéine est marqué à la His tag.

Fonction: Recombinant Human GAMT Protein (His Tag)

Séquence: Met 1-Gly236

Attributs du produit: Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,1 mMDTT, pH 8.0 .

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Autre désignation: GAMT (GAMT Produits)

Synonymes: gamt Protein, zgc:123136 Protein, CCDS2 Protein, PIG2 Protein, TP53I2 Protein, AA571402 Protein, Spintz1 Protein, MGC75698 Protein, GAMT Protein, GMT Protein, guanidinoacetate N-methyltransferase L homeolog Protein, guanidinoacetate N-methyltransferase S homeolog Protein, guanidinoacetate N-methyltransferase Protein, guanidinoacetate methyltransferase Protein, gamt.L Protein, gamt.S Protein, gamt Protein, GAMT Protein, Gamt Protein

Sujet:

Background: GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

Synonym: Guanidinoacetate N-methyltransferase, GAMT, PIG2,TP53I2

Poids moléculaire: 29.5 kDa

UniProt: Q14353