HPGD Protein (His tag)

N° du produit ABIN7320244

Détail du produit

Antigène: HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HPGD protéine est marqué à la His tag.

Fonction: Recombinant Mouse HPGD/15-PGDH Protein (His Tag)(Active)

Séquence: Met 1-Ser 269

Attributs du produit: A DNA sequence encoding the mouse HPGD (Q8VCC1) (Met 1-Ser 269) was expressed, with a polyhistide tag at the C-terusmin.

Pureté: > 90 % as determined by SDS-PAGE

Biological Activity Comment: Measured by its ability to bind Rhesus ErbB3-His in functional Elisa.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 8.0, 20 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD))

Autre désignation: HPGD/15-PGDH (HPGD Produits)

Synonymes: CBR Protein, SDR21C1 Protein, hCBR1 Protein, 15-PGDH Protein, PGDH Protein, PGDH1 Protein, PHOAR1 Protein, SDR36C1 Protein, MGC80546 Protein, MGC79454 Protein, AV026552 Protein, carbonyl reductase 1 Protein, 15-hydroxyprostaglandin dehydrogenase Protein, hydroxyprostaglandin dehydrogenase 15-(NAD) Protein, 15-hydroxyprostaglandin dehydrogenase L homeolog Protein, hydroxyprostaglandin dehydrogenase 15 (NAD) Protein, CBR1 Protein, HPGD Protein, hpgd.L Protein, hpgd Protein, pgdh Protein, Hpgd Protein, PTRG_03214 Protein, VDBG_09957 Protein

Sujet:

Background: 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.

Synonym: 15-PGDH;AV026552

Poids moléculaire: 30.6 kDa

UniProt: Q8VCC1