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IL-13 Protéine

IL13 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE Active
N° du produit ABIN7320575
  • Antigène Voir toutes IL-13 (IL13) Protéines
    IL-13 (IL13) (Interleukin 13 (IL13))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 24
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Source
    • 28
    • 14
    • 8
    • 7
    • 2
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Mouse Interleukin-13/IL-13 Protein (aa 26-131)(Active)
    Séquence
    Ser26-Phe131
    Attributs du produit
    Recombinant Mouse Interleukin-13 is produced by our E.coli expression system and the target gene encoding Ser26-Phe131 is expressed.
    Pureté
    > 95 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 1.93 ng/ml.
    Top Product
    Discover our top product IL13 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    IL-13 (IL13) (Interleukin 13 (IL13))
    Autre désignation
    Interleukin-13/IL-13 (IL13 Produits)
    Synonymes
    IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein
    Sujet

    Background: Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58 % sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.

    Synonym: Interleukin-13, IL-13, T-Cell Activation Protein P600, Il13, Il-13

    Poids moléculaire
    11.7 kDa
    UniProt
    P20109
    Pathways
    Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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