KNG1 Protein (His tag)
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- Antigène Voir toutes KNG1 Protéines
- KNG1 (Kininogen 1 (KNG1))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette KNG1 protéine est marqué à la His tag.
- Fonction
- Recombinant Human Kininogen 1/KNG1 Protein (His Tag)(Active)
- Séquence
- Gln 19-Ser 644
- Attributs du produit
- A DNA sequence encoding the human KNG1 isoform 1 (NP_001095886.1) (Gln 19-Ser 644) was fused with a polyhistidine tag at the C-terminus, and a signal peptide at the N-terminus.
- Pureté
- > 85 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC, R&D Systems, Catalog # ES009. The IC50 value is < 7 nM.
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- Discover our top product KNG1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 25 mM Tris, 100 mM NaCl, pH 7.5
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- KNG1 (Kininogen 1 (KNG1))
- Autre désignation
- Kininogen 1/KNG1 (KNG1 Produits)
- Synonymes
- BDK Protein, BK Protein, KNG Protein, Kng Protein, KNG2 Protein, fb64g01 Protein, wu:fb64g01 Protein, zgc:103569 Protein, kininogen Protein, bdk Protein, kng Protein, KNG1 Protein, IHRP Protein, KINKG Protein, KINKH Protein, Kng1 Protein, Kngk Protein, kininogen 1 Protein, kininogen 1 L homeolog Protein, inter-alpha-trypsin inhibitor heavy chain family member 4 Protein, kininogen 2-like 1 Protein, KNG1 Protein, Kng1 Protein, kng1 Protein, kng1.L Protein, ITIH4 Protein, Kng2l1 Protein
- Sujet
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Background: Kininogen-1, also known as high molecular weight kininogen, williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1 and BDK, is a secreted protein which contains three cystatin domains. Kininogen-1 / KNG1 is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood. Kininogen-1 / KNG1 circulates throughout the blood and quickly adsorbs to the material surfaces. Kininogen-1 / KNG1 is one of the early participants of the intrinsic pathway of coagulation, together with Factor XII (Hageman factor) and prekallikrein. Kininogen-1 / KNG1 is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients, in fact, had a deficiency of the same protein. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency) which is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.
Synonym: Kininogen-1; lpha-2-Thiol Proteinase Inhibitor; Fitzgerald Factor; High Molecular Weight Kininogen; HMWK; Williams-Fitzgerald-Flaujeac Factor; KNG1; BDK; KNG
- Poids moléculaire
- 71.3 kDa
- NCBI Accession
- NP_001095886
- Pathways
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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