LMCD1 Protein (His tag)
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- Antigène Voir toutes LMCD1 Protéines
- LMCD1 (LIM and Cysteine-Rich Domains 1 (LMCD1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette LMCD1 protéine est marqué à la His tag.
- Fonction
- Recombinant Human LMCD1/Dyxin Protein (His Tag)
- Séquence
- Met 1-Ser365
- Attributs du produit
- Recombinant Human LIM and cysteine-rich domains protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser365 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product LMCD1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- LMCD1 (LIM and Cysteine-Rich Domains 1 (LMCD1))
- Autre désignation
- LMCD1/Dyxin (LMCD1 Produits)
- Synonymes
- LMCD1 Protein, AW455500 Protein, AW553074 Protein, dyxin Protein, LIM and cysteine rich domains 1 Protein, LIM and cysteine-rich domains 1 Protein, LMCD1 Protein, lmcd1 Protein, Lmcd1 Protein
- Sujet
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Background: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Synonym: LIM and cysteine-rich domains protein 1, LMCD1, Dyxin
- Poids moléculaire
- 44.0 kDa
- UniProt
- Q9NZU5
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