METAP1 Protéine

N° du produit ABIN7319523

Détail du produit

Antigène: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Recombinant Human METAP1 Protein

Séquence: Met1-Phe386

Attributs du produit: Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,500 mM NaCl,10 % glycerol, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Autre désignation: METAP1 (METAP1 Produits)

Synonymes: MGC64362 Protein, METAP1 Protein, metap1 Protein, DKFZp468B1413 Protein, LOC100228334 Protein, DDBDRAFT_0205763 Protein, DDBDRAFT_0235405 Protein, DDB_0205763 Protein, DDB_0235405 Protein, MAP1A Protein, MetAP1A Protein, 1700029C17Rik Protein, AW047992 Protein, mKIAA0094 Protein, Metap1 Protein, im:7047238 Protein, wu:fc84e12 Protein, zgc:110093 Protein, methionyl aminopeptidase 1 S homeolog Protein, methionyl aminopeptidase 1 Protein, methionine aminopeptidase 1 Protein, methionyl aminopeptidase 1 L homeolog Protein, metap1.S Protein, METAP1 Protein, metap1 Protein, Metap1 Protein, metap1.L Protein

Sujet:

Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.

Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A

Poids moléculaire: 43.2 kDa

UniProt: P53582

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling