Myeloperoxidase Protein (MPO) (His tag)

N° du produit ABIN7320799

Détail du produit

Antigène: Myeloperoxidase (MPO)

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette Myeloperoxidase protéine est marqué à la His tag.

Fonction: Recombinant Mouse Myeloperoxidase/MPO Protein (His Tag)

Séquence: Met16-Thr718

Attributs du produit: Recombinant Mouse Myeloperoxidase is produced by our Mammalian expression system and the target gene encoding Met16-Thr718 is expressed with a 10His tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Myeloperoxidase (MPO)

Autre désignation: Myeloperoxidase/MPO (MPO Produits)

Synonymes: mKIAA4033 Protein, MPO Protein, LOC100335032 Protein, POX2' Protein, XPOX2' Protein, mpo Protein, mpo-A Protein, pmr-1 Protein, pmr1 Protein, pox2 Protein, xpox2 Protein, myeloperoxidase Protein, myeloperoxidase L homeolog Protein, MPO Protein, Mpo Protein, LOC100335032 Protein, mpo.L Protein

Sujet:

Background: Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of atherosclerosis. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells. MPO is stored in neutrophil azurophilic granules. Upon cellular activation, it is deposited into pathogencontaining phagosomes. While mice lacking MPO are impaired in clearing select microbial infections,MPO deficiency in humans does not necessarily result in heightened susceptibility to infections.

Synonym: Myeloperoxidase, MPO

Poids moléculaire: 81.1 kDa

UniProt: P11247

Pathways: Chromatin Binding