TRKB Protein (His tag)
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- Antigène Voir toutes TRKB (NTRK2) Protéines
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TRKB protéine est marqué à la His tag.
- Fonction
- Recombinant Rat TrkB/NTRK2 Protein (His Tag)(Active)
- Séquence
- Met1-His429
- Attributs du produit
- A DNA sequence encoding the rat NTRK2 (Q63604-Isoform T1) (Met1-His429) was expressed with a polyhistidine tag at the C-terminus.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized rat NTRK2-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse BDNF , The EC50 of biotinylated mouse BDNF is 12.2-28.6 ng/ml.
- Top Product
- Discover our top product NTRK2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
- Autre désignation
- TrkB/NTRK2 (NTRK2 Produits)
- Synonymes
- trkb Protein, trkb-b Protein, xtrkb Protein, si:ch211-220b11.1 Protein, trkB2 Protein, NTRK2 Protein, ntrk2 Protein, gp145-trkb Protein, TRKB Protein, GP145-TrkB Protein, trk-B Protein, AI848316 Protein, C030027L06Rik Protein, Tkrb Protein, trkB Protein, RATTRKB1 Protein, TRKB1 Protein, Trk-B Protein, TrkB Protein, neurotrophic receptor tyrosine kinase 2 Protein, neurotrophic receptor tyrosine kinase 2 L homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2b Protein, neurotrophic receptor tyrosine kinase 2 S homeolog Protein, neurotrophic tyrosine kinase, receptor, type 2 Protein, NTRK2 Protein, ntrk2.L Protein, ntrk2b Protein, ntrk2.S Protein, ntrk2 Protein, Ntrk2 Protein
- Sujet
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Background: TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: NTRK2;Trkb
- Poids moléculaire
- 47.1 kDa
- Pathways
- Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
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