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NOG Protein (His tag)

NOG Origine: Souris Hôte: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN7320797
  • Antigène Voir toutes NOG Protéines
    NOG (Noggin (NOG))
    Type de proteíne
    Recombinant
    Origine
    • 11
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Souris
    Source
    • 19
    • 8
    • 4
    • 3
    • 1
    Human Cells
    Purification/Conjugué
    Cette NOG protéine est marqué à la His tag.
    Fonction
    Recombinant Mouse Noggin/NOG Protein (His Tag)
    Séquence
    Gln28-Cys232
    Attributs du produit
    Recombinant Mouse Noggin is produced by our Mammalian expression system and the target gene encoding Gln28-Cys232 is expressed with a 6His tag at the C-terminus.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product NOG Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, 5 mM EDTA, 5 % Trehalose, pH 7.4.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    NOG (Noggin (NOG))
    Autre désignation
    Noggin/NOG (NOG Produits)
    Synonymes
    SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
    Sujet

    Background: Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons.

    Synonym: Noggin, Nog

    Poids moléculaire
    23.9 kDa
    UniProt
    P97466
    Pathways
    Stem Cell Maintenance, Tube Formation
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