OXSR1 Protein (GST tag)
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- Antigène Voir toutes OXSR1 Protéines
- OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))
- Type de proteíne
- Recombinant
- Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette OXSR1 protéine est marqué à la GST tag.
- Fonction
- Recombinant Human OXSR1/OSR1 Protein (GST Tag)
- Séquence
- Met 1-Ser 527
- Attributs du produit
- A DNA sequence encoding the full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus.
- Pureté
- > 88 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OXSR1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 0.5 mM GSH, 0.5 mM PMSF, 0.5 mM EDTA, 10 % glycerol
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))
- Autre désignation
- OXSR1/OSR1 (OXSR1 Produits)
- Synonymes
- OSR1 Protein, C20orf111 Protein, HSPC207 Protein, Osr1 Protein, Perit1 Protein, dJ1183I21.1 Protein, zgc:55494 Protein, zgc:77321 Protein, OXSR1 Protein, 2210022N24Rik Protein, 2810422B09Rik Protein, AI462649 Protein, AW209236 Protein, mKIAA1101 Protein, odd1 Protein, osr1 Protein, wu:fb77f12 Protein, zgc:165661 Protein, oxidative stress responsive 1 Protein, oxidative stress responsive serine rich 1 Protein, oxidative stress responsive 1b Protein, serine/threonine-protein kinase OSR1 Protein, odd-skipped related transciption factor 1 Protein, oxidative-stress responsive 1 Protein, oxidative stress responsive 1a Protein, OXSR1 Protein, OSER1 Protein, oxsr1b Protein, CpipJ_CPIJ015177 Protein, Tsp_00299 Protein, OSR1 Protein, Oxsr1 Protein, LOC106505565 Protein, oxsr1 Protein, oxsr1a Protein
- Sujet
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Background: Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39 % identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.
Synonym: OSR1
- Poids moléculaire
- 84 kDa
- NCBI Accession
- NP_005100
- Pathways
- Tube Formation
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