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PAPPA2 Protein (His tag)

PAPPA2 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
N° du produit ABIN7317837
  • Antigène Voir toutes PAPPA2 Protéines
    PAPPA2 (Pappalysin 2 (PAPPA2))
    Type de proteíne
    Recombinant
    Origine
    Humain
    Source
    • 3
    HEK-293 Cells
    Purification/Conjugué
    Cette PAPPA2 protéine est marqué à la His tag.
    Fonction
    Recombinant Human PAPPA2/Pappalysin 2 Protein (His Tag)
    Séquence
    Ser 234-Cys 1396
    Attributs du produit
    A DNA sequence encoding the human PAPPA2 mature form (NP_064714.2) corresponding to amino acid (Ser 234-Cys 1396) was expressed, with a carboxy-terminal polyhistidine tag.
    Pureté
    > 90 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product PAPPA2 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    PAPPA2 (Pappalysin 2 (PAPPA2))
    Autre désignation
    PAPPA2/Pappalysin 2 (PAPPA2 Produits)
    Synonymes
    PAPP-A2 Protein, PLAC3 Protein, Pappe Protein, PAPP-E Protein, PAPPE Protein, si:dkey-39f8.1 Protein, pappalysin 2 Protein, Pappa2 Protein, PAPPA2 Protein, pappa2 Protein
    Sujet

    Background: Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46 % of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and -II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In contrast to the cleavage of IGFBP-4 by PAPP-A that strictly requires the presence of IGF, the cleavage of IGFBP-5 by PAPP-A2 was IGF-independent. Recent data firmly establish PAPP-A and IGFBP-4 as an important functional pair in several systems. Because of its close relationship with PAPP-A, both structurally and functionally, PAPP-A2 is a likely candidate for IGFBP-5 proteinase in many tissues and conditioned media where IGFBP-5 proteolysis has been reported.

    Synonym: PAPP-A2,PAPP-E,PAPPE,PLAC3

    Poids moléculaire
    131 kDa
    NCBI Accession
    NP_064714
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