PDGFRB Protein (Fc Tag)
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- Antigène Voir toutes PDGFRB Protéines
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PDGFRB protéine est marqué à la Fc Tag.
- Fonction
- Recombinant Rat PDGFRB/CD140b Protein (Fc Tag)(Active)
- Séquence
- Met1-Lys530
- Attributs du produit
- A DNA sequence encoding the rat PDGFRB (Q05030) (Met1-Lys530) was expressed with the Fc region of human IgG1 at the C-terminus.
- Pureté
- > 90 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- 1.Measured by its binding ability in a functional ELISA.2.Immobilized mouse PDGF-B at 10μg/mL (100μL/well) can bind rat PDGFRB-Fc, the EC50 of rat PDGFRB-Fc is 0.02-0.2 μg/mL.
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- Discover our top product PDGFRB Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
- Autre désignation
- PDGFRB/CD140b (PDGFRB Produits)
- Synonymes
- AI528809 Protein, CD140b Protein, PDGFR-1 Protein, Pdgfr Protein, CD140B Protein, IBGC4 Protein, JTK12 Protein, PDGFR Protein, PDGFR1 Protein, platelet derived growth factor receptor, beta polypeptide Protein, platelet derived growth factor receptor beta Protein, Pdgfrb Protein, PDGFRB Protein
- Sujet
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Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: PDGFRB;Pdgfr;Pdgfr1;PDGFR-1
- Poids moléculaire
- 83.2 kDa
- UniProt
- Q05030
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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