Podoplanin Protein (PDPN) (Fc Tag,ECD)
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- Antigène Voir toutes Podoplanin (PDPN) Protéines
- Podoplanin (PDPN)
- Type de proteíne
- Recombinant
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Podoplanin protéine est marqué à la Fc Tag,ECD.
- Fonction
- Recombinant Rat Podoplanin/PDPN Protein (ECD, Fc Tag)
- Séquence
- Met1-Leu135
- Attributs du produit
- A DNA sequence encoding the rat Pdpn (NP_062231.1) (Met1-Leu135) was expressed with the Fc region of human IgG1 at the C-terminus.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product PDPN Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- Podoplanin (PDPN)
- Autre désignation
- Podoplanin/PDPN (PDPN Produits)
- Synonymes
- PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein
- Sujet
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Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Gp38;Ots8
- Poids moléculaire
- 38.6 kDa
- NCBI Accession
- NP_062231
- Pathways
- Dicarboxylic Acid Transport
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