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Podoplanin Protein (PDPN) (Fc Tag,ECD)

PDPN Origine: Rat Hôte: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
N° du produit ABIN7321058
  • Antigène Voir toutes Podoplanin (PDPN) Protéines
    Podoplanin (PDPN)
    Type de proteíne
    Recombinant
    Origine
    • 12
    • 9
    • 3
    • 2
    • 1
    • 1
    Rat
    Source
    • 12
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Podoplanin protéine est marqué à la Fc Tag,ECD.
    Fonction
    Recombinant Rat Podoplanin/PDPN Protein (ECD, Fc Tag)
    Séquence
    Met1-Leu135
    Attributs du produit
    A DNA sequence encoding the rat Pdpn (NP_062231.1) (Met1-Leu135) was expressed with the Fc region of human IgG1 at the C-terminus.
    Pureté
    > 95 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg protein as determined by the LAL method.
    Top Product
    Discover our top product PDPN Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    Podoplanin (PDPN)
    Autre désignation
    Podoplanin/PDPN (PDPN Produits)
    Synonymes
    PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein
    Sujet

    Background: Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Synonym: Gp38;Ots8

    Poids moléculaire
    38.6 kDa
    NCBI Accession
    NP_062231
    Pathways
    Dicarboxylic Acid Transport
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