Poliovirus Receptor Protein (PVR) (His tag)

N° du produit ABIN7321243

Détail du produit

Antigène: Poliovirus Receptor (PVR)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette Poliovirus Receptor protéine est marqué à la His tag.

Fonction: Recombinant Rat CD155/PVR/NECL5 Protein (His Tag)(Active)

Séquence: Met 1-Gly 352

Attributs du produit: A DNA sequence encoding the extracellular domain of rat PVR (NP_058772.2) (Met 1-Gly 352) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized rat CD155 at 20 μg/ml (100 μl/well) can bind mouse CD226 with a linear ranger of 6.4-160 ng/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Poliovirus Receptor (PVR)

Autre désignation: CD155/PVR/NECL5 (PVR Produits)

Synonymes: PVR Protein, CD155 Protein, HVED Protein, NECL5 Protein, Necl-5 Protein, PVS Protein, TAGE4 Protein, 3830421F03Rik Protein, D7Ertd458e Protein, Taa1 Protein, Tage4 Protein, mE4 Protein, necl-5 Protein, poliovirus receptor Protein, PVR Protein, Pvr Protein

Sujet:

Background: CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.Immune CheckpointImmune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: PVR;Taa1;Tage4

Poids moléculaire: 35.8 kDa

NCBI Accession: NP_058772

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome