PDCD1LG2 Protein (His tag)
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- Antigène Voir toutes PDCD1LG2 Protéines
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PDCD1LG2 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse B7-DC/PD-L2/CD273 Protein (His Tag)(Active)
- Séquence
- Met 1-Arg 219
- Attributs du produit
- A DNA sequence encoding the extracellular domain of mouse PDCD1LG2 (Q9WUL5) (Met 1-Arg 219) was expressed, with a C-terminal polyhistidine tag.
- Pureté
- > 95 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse PD-L2-his at 10 μg/mL (100 μl/well) can bind mouse PD1-Fc. The EC50 of mouse PD1-Fc is 1.63 μg/mL.
- Top Product
- Discover our top product PDCD1LG2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
- Autre désignation
- B7-DC/PD-L2/CD273 (PDCD1LG2 Produits)
- Synonymes
- PDL2 Protein, B7DC Protein, Btdc Protein, CD273 Protein, PD-L2 Protein, PDCD1L2 Protein, bA574F11.2 Protein, B7-DC Protein, F730015O22Rik Protein, programmed cell death 1 ligand 2 Protein, PDCD1LG2 Protein, Pdcd1lg2 Protein
- Sujet
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Background: Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Programmed cell death 1 ligand 2;Pdcd1lg2;PD-1 ligand 2;PD-L2; PDCD1 ligand 2; B7-DC; CD273;Btdc;F730015O22Rik;PD-L2
- Poids moléculaire
- 24 kDa
- UniProt
- Q9WUL5
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