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PTPN12 Protéine

PTPN12 Origine: Humain Hôte: Baculovirus infected Insect Cells Recombinant > 85 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7317537
  • Antigène Voir toutes PTPN12 Protéines
    PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 7
    • 2
    Humain
    Source
    • 3
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Fonction
    Recombinant Human PTPN12 Protein (Active)
    Séquence
    Met 1-Gln355
    Attributs du produit
    A DNA sequence encoding the human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
    Pureté
    > 85 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site .The specific activity is >20 mol/min/mg
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    Discover our top product PTPN12 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
    Autre désignation
    PTPN12 (PTPN12 Produits)
    Synonymes
    PTP-PEST Protein, PTPG1 Protein, P19-PTP Protein, PTP-P19 Protein, Ptpg1 Protein, RKPTP Protein, protein tyrosine phosphatase, non-receptor type 12 Protein, PTPN12 Protein, Ptpn12 Protein
    Sujet

    Background: PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobilit.

    Synonym: PTP-PEST,PTPG1

    Poids moléculaire
    41.8 kDa
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