s100a4 Protéine

N° du produit ABIN7197760

Détail du produit

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Fonction: Recombinant Mouse S100A4 Protein

Séquence: Ala2-Lys101

Attributs du produit: A DNA sequence encoding the mouse S100A4 (P07091)(Ala2-Lys101) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.

Pureté: > 85 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Autre désignation: S100A4 (S100A4 Produits)

Synonymes: 18A2 Protein, 42A Protein, CAPL Protein, FSP1 Protein, MTS1 Protein, P9KA Protein, PEL98 Protein, 42a Protein, Capl Protein, FSp1 Protein, Mts1 Protein, PeL98 Protein, metastasin Protein, pk9a Protein, S100A4 Protein, P9ka Protein, RNP9KA Protein, S100 calcium binding protein A4 Protein, S100 calcium-binding protein A4 Protein, S100A4 Protein, S100a4 Protein

Sujet:

Background: S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

Synonym: 18A2,42a,Capl,FSp1,metastasin,Mts1,PeL98,pk9a

Poids moléculaire: 11.7 kDa

UniProt: P07091

Pathways: S100 Proteins