SLAMF8 Protein (His tag)
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- Antigène Voir toutes SLAMF8 Protéines
- SLAMF8 (SLAM Family Member 8 (SLAMF8))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette SLAMF8 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse SLAMF8 Protein (His Tag)(Active)
- Séquence
- Met 1-Asp 231
- Attributs du produit
- A DNA sequence encoding the mouse SLAMF8 (NP_083360.2) extracellular domain (Met 1-Asp 231) was fused with the a polyhistidine tag at the C-terminus.
- Pureté
- > 80 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind biotinylated mouse SLAMF8 in a functional ELISA.
- Top Product
- Discover our top product SLAMF8 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- SLAMF8 (SLAM Family Member 8 (SLAMF8))
- Autre désignation
- SLAMF8 (SLAMF8 Produits)
- Synonymes
- BLAME Protein, CD353 Protein, SBBI42 Protein, 5830408F06Rik Protein, Blame Protein, SLAM family member 8 Protein, Slamf8 Protein, slamf8 Protein, SLAMF8 Protein
- Sujet
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Background: The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
Synonym: SLAM family member 8; B-lymphocyte activator macrophage expressed; CD353; Slamf8; Blame;SBBI42
- Poids moléculaire
- 24.8 kDa
- NCBI Accession
- NP_083360
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