Stanniocalcin 1 Protein (STC1) (His tag)

N° du produit ABIN7319806

Détail du produit

Antigène: Stanniocalcin 1 (STC1)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Stanniocalcin 1 protéine est marqué à la His tag.

Fonction: Recombinant Human Stanniocalcin 1/STC-1 (C-6His)

Séquence: Thr18-Ala247

Attributs du produit: Recombinant Human Stanniocalcin 1 is produced by our Mammalian expression system and the target gene encoding Thr18-Ala247 is expressed with a 6His tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Stanniocalcin 1 (STC1)

Autre désignation: Stanniocalcin 1/STC-1 (STC1 Produits)

Synonymes: STC Protein, Stc Protein, stc1 Protein, MGC82280 Protein, STC1 Protein, zgc:153307 Protein, LOC777959 Protein, stanniocalcin 1 Protein, stanniocalcin 1 L homeolog Protein, stanniocalcin 1 S homeolog Protein, STC1 Protein, Stc1 Protein, stc1.L Protein, stc1.S Protein, stc1 Protein, LOC777959 Protein

Sujet:

Background: Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius. STC-1 inhibits the breakdown of PAPP-A, protects cancer cells from apoptosis, reduces tumor size of liver cancers, promotes osteoblast differentiation and inhibits longitudinal bone growth directly at the growth plate. It is also a biomarker of brain and lung cancer progression. STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.

Synonym: Stanniocalcin 1, stanniocalcin-1, STC1, STC-1, STCSTC-1

Poids moléculaire: 26.9 kDa

UniProt: P52823

Pathways: Hormone Activity