SNAP25 Protein (His tag)

N° du produit ABIN7317532

Détail du produit

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SNAP25 protéine est marqué à la His tag.

Fonction: Recombinant Human SNAP25/SUP Protein (His Tag)

Séquence: Met 1-Gly 206

Attributs du produit: A DNA sequence encoding the human SNAP25 (P60880-1) (Met 1-Gly 206) was expressed, with a polyhistide tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Autre désignation: SNAP25/SUP (SNAP25 Produits)

Synonymes: RIC-4 Protein, RIC4 Protein, SEC9 Protein, SNAP Protein, SNAP-25 Protein, bA416N4.2 Protein, dJ1068F16.2 Protein, SNAP-25B Protein, SNAP-25a Protein, ric-4 Protein, ric4 Protein, sec9 Protein, snap-25 Protein, Bdr Protein, sp Protein, fj55h11 Protein, snap25 Protein, wu:fj55h11 Protein, Snap Protein, snap25.2 Protein, wu:fj33h05 Protein, synaptosome associated protein 25 Protein, synaptosome associated protein 25kDa S homeolog Protein, synaptosomal-associated protein, 25kDa Protein, synaptosomal-associated protein 25 Protein, synaptosome associated protein 25kDa Protein, synaptosome associated protein 25kDa L homeolog Protein, zgc:101731 Protein, synaptosomal-associated protein, 25b Protein, SNAP25 Protein, Snap25 Protein, snap25.S Protein, snap25 Protein, BACOIKO003_07 Protein, Tsp_10811 Protein, snap25.L Protein, zgc:101731 Protein, snap25b Protein

Sujet:

Background: Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein which belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25 / SUP is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25 / SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25 / SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25 / SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25 / SUP inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25 / SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.

Synonym: bA416N4.2;dJ1068F16.2;RIC-4;RIC4;SEC9;SNAP;SNAP-25

Poids moléculaire: 24.8 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport