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Thrombopoietin Protein (THPO) (His tag)

THPO Origine: Humain Hôte: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7319081
  • Antigène Voir toutes Thrombopoietin (THPO) Protéines
    Thrombopoietin (THPO)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 11
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    Humain
    Source
    • 25
    • 2
    • 2
    • 2
    • 1
    • 1
    Human Cells
    Purification/Conjugué
    Cette Thrombopoietin protéine est marqué à la His tag.
    Fonction
    Recombinant Human Thrombopoietin/TPO Protein (His Tag)(Active)
    Séquence
    Ser22-Gly353
    Attributs du produit
    Recombinant Human Thrombopoietin is produced by our Mammalian expression system and the target gene encoding Ser22-Gly353 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured in a cell proliferation assay using MO7E human megakaryocytic leukemic cells. The ED50 for this effect is 0.55 ng/ml.
    Top Product
    Discover our top product THPO Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    Thrombopoietin (THPO)
    Autre désignation
    Thrombopoietin/TPO (THPO Produits)
    Synonymes
    MGDF Protein, MKCSF Protein, ML Protein, MPLLG Protein, THCYT1 Protein, TPO Protein, Mgdf Protein, Ml Protein, Mpllg Protein, Tpo Protein, Tpo1 Protein, Tpo2 Protein, Tpo3 Protein, Tpo4 Protein, tpo Protein, LOC100231762 Protein, thrombopoietin Protein, THPO Protein, Thpo Protein, thpo Protein
    Sujet

    Background: Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

    Synonym: Thrombopoietin,C-mpl ligand,Megakaryocyte colony-stimulating factor,Megakaryocyte growth and development factor,Myeloproliferative leukemia virus oncogene ligand,THPO

    Poids moléculaire
    37.3 kDa
    UniProt
    P40225
    Pathways
    Signalistation JAK/STAT, Hormone Activity
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