TLK2 Protéine

N° du produit ABIN7317071

Détail du produit

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Fonction: Recombinant Human TLK2/PKU-ALPHA Protein

Séquence: Leu 397-Asn772

Attributs du produit: A DNA sequence encoding the human TLK2 (Q86UE8-1) (Leu397-Asn772) was fused with two additional amino acids (Gly & Pro) at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Autre désignation: TLK2/PKU-ALPHA (TLK2 Produits)

Synonymes: tlk2 Protein, MGC149057 Protein, HsHPK Protein, PKU-ALPHA Protein, wu:fi16h09 Protein, wu:fi30g12 Protein, zgc:136697 Protein, 4933403M19Rik Protein, PKUalpha Protein, Tlk Protein, tousled like kinase 2 Protein, tousled-like kinase 2 Protein, tousled-like kinase 2 (Arabidopsis) Protein, tlk2 Protein, TLK2 Protein, Tlk2 Protein

Sujet:

Background: Serine / threonine-protein kinase tousled-like 2; also known as PKU-alpha; Tousled-like kinase 2 and TLK2; is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair; DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta; liver; kidney; pancreas; heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

Synonym: HsHPK;PKU-ALPHA

Poids moléculaire: 43.6 kDa