TGFB1 Protéine

N° du produit ABIN7320668

Détail du produit

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Human Cells

Fonction: Recombinant Mouse TGFβ1/TGFB1 Protein (Active)

Séquence: Ala279-Ser390

Attributs du produit: Recombinant Mouse Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit IL-4-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 5-25 pg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM Glycine,150 mM NaCl, pH 2.5.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Autre désignation: TGFbeta1/TGFB1 (TGFB1 Produits)

Synonymes: CED Protein, DPD1 Protein, LAP Protein, TGFB Protein, TGFbeta Protein, TGF-beta Protein, TGF-BETA-1 Protein, TGF-beta5 Protein, ced Protein, dpd1 Protein, lap Protein, tgf-beta Protein, tgfb Protein, tgfb5 Protein, tgfbeta Protein, TGF-beta1 Protein, TGFbeta1 Protein, Tgfb Protein, Tgfb-1 Protein, ai39657 Protein, tgfb1 Protein, wu:fb13a07 Protein, xx:ai39657 Protein, TGFB1 Protein, csd Protein, cdb1 Protein, cdg2 Protein, csd1 Protein, csd2 Protein, csd3 Protein, ebmd Protein, lcd1 Protein, bigh3 Protein, cdgg1 Protein, betaig-h3 Protein, TGFB4 Protein, transforming growth factor beta 1 Protein, transforming growth factor beta-1 Protein, transforming growth factor beta 1 L homeolog Protein, transforming growth factor, beta 1 Protein, transforming growth factor, beta 1a Protein, transforming growth factor beta induced L homeolog Protein, TGFB1 Protein, Tgfb1 Protein, tgfb1.L Protein, tgfb1a Protein, tgfbi.L Protein

Sujet:

Background: Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.

Synonym: TGF-beta-1, CED, DPD1, TGFB, TGF-b1, TGFB1, CEDLAP,latency-associated peptide, TGFbeta, TGF-beta 1 protein, transforming growth factor beta-1

Poids moléculaire: 12.8 kDa

UniProt: P04202

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints