CD300LB Protein (Fc Tag)
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- Antigène Voir toutes CD300LB (TREM5) Protéines
- CD300LB (TREM5) (Triggering Receptor Expressed On Myeloid Cells 5 (TREM5))
- Type de proteíne
- Recombinant
- Origine
- Humain
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Source
- Human Cells
- Purification/Conjugué
- Cette CD300LB protéine est marqué à la Fc Tag.
- Fonction
- Recombinant Human CD300LB/LMIR5 (C-Fc)
- Séquence
- Ile55-His187
- Attributs du produit
- Recombinant Human CD300LB is produced by our Mammalian expression system and the target gene encoding Ile55-His187 is expressed with a Fc tag at the C-terminus.
- Pureté
- >95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TREM5 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- CD300LB (TREM5) (Triggering Receptor Expressed On Myeloid Cells 5 (TREM5))
- Autre désignation
- CD300LB/LMIR5 (TREM5 Produits)
- Synonymes
- CLM-7 Protein, Clm7 Protein, Gm253 Protein, LMIR5 Protein, CD300b Protein, CLM7 Protein, CMRF35-A2 Protein, IREM-3 Protein, IREM3 Protein, TREM-5 Protein, TREM5 Protein, CD300 molecule like family member B Protein, CD300 molecule like family member b Protein, triggering receptor expressed on myeloid cells 5 Protein, Cd300lb Protein, CD300LB Protein, Trem5 Protein
- Sujet
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Background: CD300LB, also known as CD300b, LMIR5, CLM-7, and IREM-3, is a glycoprotein member of the immunoglobulin superfamily. LMIR5 is expressed on the surface of myeloid lineage cells. It forms noncovalent cis-homodimers and cis-heterodimers with other CD300 family proteins, and the composition of these dimers affects the cellular response. Antibody cross-linking of LMIR5 induces mast cell granule release and cytokine production as well as its tyrosine phosphorylation of LMIR5 (in human). LMIR5 interacts with TIM1 and TIM4 which regulate T cell activation and are themselves binding partners. TIM1 interactions with LMIR5 mediate mast cell activation and the accumulation of neutrophils at sites of TIM1 up-regulation on damaged renal tubule epithelial cells. Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
Synonym: CD300b, CLM-7, CLM-7, CMRF35-A2, IREM-3, IREM3, TREM-5, TREM5, CD300LB
- Poids moléculaire
- 42.2 kDa
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