USP46 Protéine

N° du produit ABIN7317327

Détail du produit

Antigène: USP46 (Ubiquitin Specific Peptidase 46 (USP46))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Fonction: Recombinant Human/Mouse USP46 Protein

Séquence: Met 1-Glu366

Attributs du produit: A DNA sequence encoding the human USP46 [(Identical to the mouse USP46 (NP_808229.1)] (Met1-Glu366) was fused with the SUMO tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: USP46 (Ubiquitin Specific Peptidase 46 (USP46))

Autre désignation: / USP46 (USP46 Produits)

Synonymes: RGD1564808 Protein, usp46 Protein, MGC53480 Protein, 1190009E20Rik Protein, 2410018I08Rik Protein, AI451644 Protein, si:ch73-16a12.1 Protein, ubiquitin specific peptidase 46 Protein, ubiquitin specific peptidase 46 S homeolog Protein, Usp46 Protein, usp46.S Protein, USP46 Protein, usp46 Protein

Sujet:

Background: USP46 belongs to the peptidase C19 family, USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolyases, ubiquitin isopeptidases, or Dubs. They regulate ubiquitin-dependent metabolic pathways by cleaving ubiquitin-protein bonds. They also may act as negative and positive regulators of the ubiquitin system. Besides ubiquitin recycling, they are also involved in processing of ubiquitin precursors, in proofreading of protein ubiquitination and in disassembly of inhibitory ubiquitin chains. USP46 is a deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. It may act by mediating the deubiquitination of GAD1/GAD67. USP46 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity and it is not involved in deubiquitination of monoubiquitinated FANCD2.

Synonym: USP46

Poids moléculaire: 42.4 kDa

NCBI Accession: NP_808229