UBE2A Protein (His tag)
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- Antigène Voir toutes UBE2A (ube2a) Protéines
- UBE2A (ube2a) (Ubiquitin-Conjugating Enzyme E2A (ube2a))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette UBE2A protéine est marqué à la His tag.
- Fonction
- Recombinant Human UBE2A Protein (His Tag)
- Séquence
- Met 1-Cys 152
- Attributs du produit
- A DNA sequence encoding the mature form of human UBE2A (P49459) (Met 1-Cys 152) was expressed, with a polyhistidine tag at the N-terminus.
- Pureté
- > 80 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ube2a Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, 20 % glycerol, pH 7.5
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- UBE2A (ube2a) (Ubiquitin-Conjugating Enzyme E2A (ube2a))
- Autre désignation
- UBE2A (ube2a Produits)
- Synonymes
- BHR6A Protein, HR6A Protein, hhr6a Protein, rad6a Protein, ubc2 Protein, mp:zf637-2-000771 Protein, si:bz46j2.4 Protein, wu:fa01h11 Protein, HHR6A Protein, MRXS30 Protein, MRXSN Protein, RAD6A Protein, UBC2 Protein, Mhr6a Protein, ubiquitin conjugating enzyme E2 A Protein, ubiquitin conjugating enzyme E2 A L homeolog Protein, ubiquitin-conjugating enzyme E2A (RAD6 homolog) Protein, ubiquitin-conjugating enzyme E2A Protein, UBE2A Protein, ube2a.L Protein, ube2a Protein, Ube2a Protein
- Sujet
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Background: Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A); encoded by human DNA repair genes HHR6A; belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene; a member of the family of ubiquitin-conjugating enzymes. In vivo; HHR6A phosphorylation peaks during the G2/M phase of cell cycle transition; with a concomitant increase in histone H2B ubiquitylation. Mutation of Ser120 to threonine or alanine abolished UBE2A activity; while mutation to aspartate to mimic phosphorylated serine increased UBE2A activity 3-fold. A mutation of UBE2A is consisdered as the cause of a novel X-linked mental retardation (XLMR) syndrome that affects three males in a two-generation family.
Synonym: Ubiquitin-Conjugating Enzyme E2 A; RAD6 Homolog A; HR6A; hHR6A; Ubiquitin Carrier Protein A; Ubiquitin-Protein Ligase A; UBE2A; RAD6A
- Poids moléculaire
- 19.2 kDa
- UniProt
- P49459
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